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Curr Opin Immunol. 1995 Dec;7(6):757-61.

Peptide modulation of allergen-specific immune responses.

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Imperial College of Science, Technology and Medicine, London, UK.


In vitro peptide stimulation of allergen-reactive T-helper type 1 and type 0 cells, in the absence of costimulatory signals, induces anergy that is accompanied by the modulation of cell surface phenotype and changes in cytokine production. In experimental animal models, the administration of allergen-derived peptides may result in the downregulation of cytokine and antibody production, which is preceded by transient activation of CD4+ T cells, without the induction of effector immunity. Preliminary results of clinical trials using allergen-derived peptides for desensitization are becoming available and should provide some insight into the efficacy of peptide therapy in man.

[Indexed for MEDLINE]

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