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Biophys Chem. 1996 Apr 16;59(3):329-39.

Recent developments in the theory of protein folding: searching for the global energy minimum.

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Baker Laboratory of Chemistry, Cornell University, Ithaca, NY 14853-1301, USA.


Statistical mechanical theories and computer simulation are being used to gain an understanding of the fundamental features of protein folding. A major obstacle in the computation of protein structures is the multiple-minima problem arising from the existence of many local minima in the multidimensional energy landscape of the protein. This problem has been surmounted for small open-chain and cyclic peptides, and for regular-repeating sequences of models of fibrous proteins. Progress is being made in resolving this problem for globular proteins.

[Indexed for MEDLINE]

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