Format

Send to

Choose Destination
Biophys Chem. 1996 Apr 16;59(3):329-39.

Recent developments in the theory of protein folding: searching for the global energy minimum.

Author information

1
Baker Laboratory of Chemistry, Cornell University, Ithaca, NY 14853-1301, USA.

Abstract

Statistical mechanical theories and computer simulation are being used to gain an understanding of the fundamental features of protein folding. A major obstacle in the computation of protein structures is the multiple-minima problem arising from the existence of many local minima in the multidimensional energy landscape of the protein. This problem has been surmounted for small open-chain and cyclic peptides, and for regular-repeating sequences of models of fibrous proteins. Progress is being made in resolving this problem for globular proteins.

PMID:
8672720
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center