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Biochim Biophys Acta. 1996 Jun 7;1287(2-3):103-20.

Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins.

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Division of Molecular Carcinogenesis, The Netherlands Cancer Institute,Amsterdam, The Netherlands.


The retinoblastoma family of growth-inhibitory proteins act by binding and inhibiting several proteins with growth-stimulatory activity, the most prominent of which is the cellular transcription factor E2F. In higher organisms, progression through the cell division cycle is accompanied by the cyclical activation of a number of protein kinases, the cyclin-dependent kinases. Phosphorylation of retinoblastoma family proteins by these cyclin-dependent kinases leads to release of the associated growth-stimulatory proteins which in turn mediate progression through the cell division cycle.

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