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Arthritis Rheum. 1996 Jul;39(7):1138-45.

Comprehensive noninvasive assessment of cardiac involvement in limited systemic sclerosis.

Author information

1
Hospital General Universitari Vall d'Hebron, Barcelona, Spain.

Abstract

OBJECTIVE:

To assess cardiovascular abnormalities in patients with limited systemic sclerosis (SSc), using noninvasive cardiac techniques.

METHODS:

Sixty-three patients with limited SSc were prospectively evaluated with Doppler echocardiography and thallium-201 perfusion scintigraphy after a cold-stress test and radionuclide ventriculography.

RESULTS:

In the patients with limited SSc, there was a significantly high prevalence of abnormal left- and right-diastolic function parameters (P = 0.001 and P = 0.0002, respectively), thickening of papillary muscles (46%; P = 0.003), and mild mitral regurgitation (49%; P < 0.0001), compared with controls. Systolic pulmonary arterial hypertension was detected in 9 patients (14%), and pericardial effusion in 11 patients (18%). In 64% of patients with limited SSc, an ischemic response was detected on the thallium cold-stress scan; similarly, an ischemic response was detected in 57% of patients with primary Raynaud's phenomenon (P < 0.0001 versus controls).

CONCLUSION:

Although the frequency of cardiovascular symptoms was low in patients with limited SSc, a significant rate of cardiovascular abnormalities was found by noninvasive cardiac techniques.

PMID:
8670322
DOI:
10.1002/art.1780390710
[Indexed for MEDLINE]

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