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Anticancer Res. 1995 Nov-Dec;15(6B):2797-8.

Lack of expression of c-erbB-2 oncoprotein in human esophageal squamous cell carcinomas.

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Department of Pathology, Norwegian Radium Hospital, Oslo, Norway.


Fifty-one cases of esophageal squamous cell carcinoma were immunohistochemically investigated with monoclonal c-erbB 2 oncoprotein antibody. No tumor showed plasma membrane immunostaining for c-erbB-2 protein. Occasionally, unspecific cytoplasmic staining was found in minor tumor cell populations. The present results show that c-erbB-2 oncoprotein is not overexpressed in esophageal squamous cell carcinomas and does not play a central role in the tumorigenesis.

[Indexed for MEDLINE]

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