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Anticancer Res. 1995 Nov-Dec;15(6B):2495-9.

Somatic mutations in the neurofibromatosis 1 gene in gliomas and primitive neuroectodermal tumours.

Author information

1
Institut fur Medizinische Genetik, Universitätsklinikum, Berlin, Germany.

Abstract

The increased frequency of glioma among neurofibromatosis 1 (NF1) patients suggests a general involvement of the NF1 gene in glioma tumourigenesis. Using the methodology of conventional Southern blotting with a complete panel of overlapping partial cDNAs covering the whole NF1 gene, we screened 31 gliomas of several different subtypes and 3 primitive neuroectodermal tumours (PNETs) from non-NF1 patients for aberrant restriction patterns in their tumour DNA samples. Clear evidence for somatic mutation events at the NF1 gene locus was found in 1 astrocytoma, 2 glioblastomas, 1 ependymoma and 1 PNET with an astrocytic component. These results suggest that the NF1 gene is important in suppressing tumours of neuroectodermal origin.

PMID:
8669813
[Indexed for MEDLINE]

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