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Ann Emerg Med. 1996 Jul;28(1):1-6.

Hemodynamic effects of calcium chloride in a canine model of acute propranolol intoxication.

Author information

1
Georgetown-George Washington Emergency Medicine Residency, Washington, DC, USA.

Abstract

STUDY OBJECTIVE:

To evaluate the hemodynamic effects of calcium chloride in a canine model of acute propranolol toxicity.

METHODS:

Two minutes after the completion of a propranolol infusion (10 mg/kg), a bolus of .125 mL/kg 10% CaCl solution followed by an infusion of .375 mL/kg over the next 30 minutes or a bolus and subsequent infusion of an equivalent volume of normal saline solution was administered to each dog.

RESULTS:

CaCl yielded significant improvements in propranolol-induced decreases in cardiac index and stroke volume compared with saline solution-treated control animals (overall alpha = .05). Furthermore, CaCl administration resulted in earlier improvement in propranolol-induced alterations in mean arterial pressure, maximal left ventricular pressure change over time, and peripheral vascular resistance compared with saline solution (overall alpha = .05). We observed no difference between treatment groups in response to propranolol-induced bradycardia or QRS-interval prolongation.

CONCLUSION:

In this model of acute propranolol toxicity, CaCl therapy improved depressed hemodynamic status, mainly by a positive inotropic action.

PMID:
8669723
DOI:
10.1016/s0196-0644(96)70129-4
[Indexed for MEDLINE]

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