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Radiology. 1996 May;199(2):433-40.

Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis.

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1
Department of Radiology, Michael Reese Hospital, Chicago, IL 60616, USA.

Abstract

PURPOSE:

To determine the natural history of intracranial calcifications in infants with treated congenital toxoplasmosis.

MATERIALS AND METHODS:

Between January 1982 and March 1994, cranial computed tomography was performed in 56 infants with treated congenital toxoplasmosis when they were newborns and approximately 1 year old. Locations and sizes of intracranial calcifications were noted.

RESULTS:

Forty newborns had intracranial calcifications. By 1 year of age, calcifications diminished or resolved in 30 (75%) and remained stable in 10 (25%) of these treated infants. Ten (33%) of the 30 infants whose calcifications diminished versus seven (70%) of the 10 infants with stable calcifications received less intensive antimicrobial treatment than the other treated infants. In contrast, a small number of infants who were untreated or treated 1 month or less had intracranial calcifications that increased or remained stable during their 1st year of life.

CONCLUSION:

Diminution or resolution of intracranial calcifications was an unexpected and remarkable finding in infants with treated, congenital toxoplasmosis, consonant with their improved neurologic functioning.

[Indexed for MEDLINE]

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