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J Med Chem. 1996 May 24;39(11):2123-8.

Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists.

Author information

1
Hauptlaboratorium, BASF AG, Ludwigshafen, Germany.

Abstract

A novel class of endothelin-A receptor ligands was discovered by high-throughput screening. Lead structure optimization led to highly potent antagonists which can be synthesized in a short sequence. The compounds are endothelin-A-selective, are orally available, and show a long duration of action.

PMID:
8667356
DOI:
10.1021/jm960274q
[Indexed for MEDLINE]

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