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J Chemother. 1995 Dec;7(6):525-9.

In-vitro activity of commonly used antifungal agents in the presence of rifampin, polymyxin B and norfloxacin against Candida albicans.

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1
College of Pharmacy, Division of Microbiology, King Saud University, Riyadh, Saudi Arabia.

Abstract

This study assessed the in-vitro antifungal activity against Candida albicans of amphotericin B, ketoconazole and miconazole, each in the presence of rifampin, polymyxin B and norfloxacin. Evaluation of drug interactions was estimated by the checkerboard pattern broth dilution method and by time-kill studies. Rifampin reduced the activity of the three antifungal agents used, with the reduction being more pronounced with amphotericin B. Synergy was observed when polymyxin B was combined with any of the antifungal agents used. The addition of norfloxacin resulted in minimal, if any, change in the activity.

PMID:
8667037
DOI:
10.1179/joc.1995.7.6.525
[Indexed for MEDLINE]
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