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J Exp Med. 1996 Apr 1;183(4):1857-64.

Antibody response to a T-dependent antigen requires B cell expression of complement receptors.

Author information

1
Graduate Program in Immunology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205-2196, USA.

Abstract

Several lines of evidence indicate that antibody responses to T-dependent antigens require complement receptors expressed on either B lymphocytes or follicular dendritic cells. We have used RAG-2 deficient blastocyst complementation to create mice specifically lacking B cell complement receptors. Despite normal expression of complement receptor 1 (CR1[CD35]) and CR2 (CD21) on follicular dendritic cells, these mice have a profound defect in their capacity to mount a T-dependent antibody response. This is the first direct demonstration in vivo that B cell expression of complement receptors is required for a humoral immune response. This is the first direct demonstration in vivo that B cell expression of complement receptors is required for a humoral immune response. This suggests that CD21 and/or CD35 on B lymphocytes may be required for cellular activation, adsorptive endocytosis of antigen, recruitment to germinal centers, and/or protection from apoptosis during the humoral response to T-dependent antigens.

PMID:
8666942
PMCID:
PMC2192488
DOI:
10.1084/jem.183.4.1857
[Indexed for MEDLINE]
Free PMC Article

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