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FEMS Microbiol Lett. 1996 Jun 15;140(1):65-70.

TonB-dependent iron supply in Salmonella by alpha-ketoacids and alpha-hydroxyacids.

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Department of Microbiology and Immunology, University of Leicester, UK.


A range of structurally diverse alpha-ketoacids and alpha-hydroxyacids promoted the growth of isolates of Salmonella serovars S. typhimurium, S. enteritidis, S. agona, S. paratyphi and S. stanleyville in iron restricted conditions in the absence of functional siderophores. Growth stimulation, observed both in cross-feeding tests on solid medium and in liquid cultures, and uptake of 55Fe in the presence of alpha-ketoisocaproic acid, were TonB dependent in S. typhimurium. In this respect the mechanism is distinct from a previously described Serratia marcescens system (sfuABC); the presence of the cloned sfuABC genes mediated tonB-independent uptake by S. typhimurium of iron complexed with alpha-ketoacids.

[Indexed for MEDLINE]

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