Format

Send to

Choose Destination
See comment in PubMed Commons below
J Cardiovasc Risk. 1995 Dec;2(6):545-9.

White-coat hypertension and cardiovascular risk.

Author information

1
Internal Medicine and Hypertension Center, University of Palermo, Italy.

Abstract

OBJECTIVE:

To compare cardiovascular risk in white-coat hypertensives, normotensives and established hypertensives.

METHODS:

We studied 61 hypertensive individuals, 27 of whom were white-coat hypertensives, and 35 normotensives. All subjects underwent 24 h noninvasive blood pressure monitoring and Doppler echocardiographic examination of the heart; urine was tested for microalbuminuria and the fundi of the eyes examined for retinopathy.

RESULTS:

The 24 h as well as the day- and night-time mean systolic blood pressure (SBP) was slightly but significantly higher in white-coat hypertensives than in normotensives; no significant difference was observed in diastolic blood pressure (DBP) between these groups. In white-coat hypertensives, 24 h SBP and DBP were lower than in established hypertensives (P < 0.001). The echocardiographic study showed higher values of posterior wall thickness, left ventricular mass index (LVMI), and ventricular septum thickness (P < 0.05) in white-coat hypertensives than in normotensives; fractional shortening and ejection fraction were similar. The E:A ratio, obtained from the Doppler study, was lower in white-coat hypertensives than in normotensives (1.14 +/- 0.3 versus 1.24 +/- 0.25; P < 0.05). LVMI values were smaller in white-coat hypertensives than in established hypertensives (P < 0.05), and both ejection fraction and fractional shortening were similar in the two groups. Among white-coat hypertensives, eight out of 27 showed hypertensive retinal damage; microalbuminuria values were similar to those obtained in normotensives.

CONCLUSIONS:

The results of this cross-sectional and therefore limited study lead us to hypothesize that white-coat hypertensives are at higher risk than normotensives and lower risk than established hypertensives for developing cardiovascular damage.

PMID:
8665373
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center