Send to

Choose Destination
J Heart Valve Dis. 1996 Mar;5(2):235-7.

Aortic and mitral valve disease induced by ergotamine therapy for migraine: a case report and review of the literature.

Author information

Department of Cardiac Surgery, University Hospital Gasthuisberg, Universitaire Ziekenhuizen Leuven, Belgium.


A case of aortic and mitral valve disease associated with ergotamine abuse is reported. A 34-year-old woman presented with dyspnea after a long standing history of peripheral vascular pathology associated with ergotamine abuse. Cardiac dysfunction was rapidly progressive. At surgery, nodular thickening of both valves and fusion of the posterior leaflet of the mitral valve were seen. Microscopy revealed proliferation of myofibroblasts with little destruction of normal valvular elements. The similarity to lesions in carcinoid heart disease and in methysergide-associated valvular disease suggests direct stimulation of myofibroblast growth by serotonin agonist effect.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center