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Neuron. 1996 Jun;16(6):1147-57.

Long-term potentiation in cultures of single hippocampal granule cells: a presynaptic form of plasticity.

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Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA.


We have explored the mechanisms of mossy fiber long-term potentiation (LTP) at autapses in single-cell cultures of guinea pig hippocampal dentate granule cells. L-AP4-sensitive, but not insensitive, cells responded to a brief tetanus with a sustained potentiation in the synaptic responses. The induction of this LTP appeared identical to that observed in hippocampal mossy fiber synapses in situ, in that it required a rise in presynaptic Ca2+ and activation of protein kinase A. Its expression also appeared to be presynaptic and was due, at least in part, to events that occurred after the entry of Ca2+ and to the switching on of previously silent release sites.

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