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Science. 1996 Jul 12;273(5272):228-31.

Mechanism of suppression of cell-mediated immunity by measles virus.

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Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Erratum in

  • Science 1997 Feb 21;275(5303):1053.


The mechanisms underlying the profound suppression of cell-mediated immunity (CMI) accompanying measles are unclear. Interleukin-12 (IL-12), derived principally from monocytes and macrophages, is critical for the generation of CMI. Measles virus (MV) infection of primary human monocytes specifically down-regulated IL-12 production. Cross-linking of CD46, a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression. CD46 provides a regulatory link between the complement system and cellular immune responses.

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