Format

Send to

Choose Destination
Virology. 1996 Jun 15;220(2):530-4.

HIV-1 Gag protein associates with F-actin present in microfilaments.

Author information

1
Department of Pediatrics, School of Medicine, University of California at Los Angeles 90095, USA. <orey@pediatrics.medsch.ucla.edu>

Abstract

Several studies have provided evidence that the cellular cytoskeleton may be involved in the assembly and budding of retroviruses. In fractionation studies of HIV-1-infected CEM cells, the majority of the unprocessed Gag polyprotein cofractionated with the cellular cytoskeleton. In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1.

PMID:
8661406
DOI:
10.1006/viro.1996.0343
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center