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Science. 1996 Jun 14;272(5268):1646-9.

Thymine-thymine dimer bypass by yeast DNA polymerase zeta.

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  • 1Department of Biophysics, School of Medicine and Dentistry, University of Rochester Medical Center, New York 14642, USA.


The REV3 and REV7 genes of the yeast Saccharomyces cerevisiae are required for DNA damage-induced mutagenesis. The Rev3 and Rev7 proteins were shown to form a complex with DNA polymerase activity. This polymerase replicated past a thymine-thymine cis-syn cyclobutane dimer, a lesion that normally severely inhibits replication, with an efficiency of approximately 10 percent. In contrast, bypass replication efficiency with yeast DNA polymerase alpha was no more than 1 percent. The Rev3-Rev7 complex is the sixth eukaryotic DNA polymerase to be described, and is therefore called DNA polymerase zeta.

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