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Nature. 1996 Jun 27;381(6585):796-800.

Transduction of bitter and sweet taste by gustducin.

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1
Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York 10029, USA.

Erratum in

  • Nature 1996 Oct 10;383(6600):557.

Abstract

Several lines of evidence suggest that both sweet and bitter tastes are transduced via receptors coupled to heterotrimeric guanine-nucleotide-binding proteins (G proteins). Gustducin is a taste receptor cell (TRC)-specific G protein that is closely related to the transducins. Gustducin and rod transducin, which is also expressed in TRCs, have been proposed to couple bitter-responsive receptors to TRC-specific phosphodiesterases to regulate intracellular cyclic nucleotides. Here we investigate gustducin's role in taste transduction by generating and characterizing mice deficient in the gustducin alpha-subunit (alpha-gustducin). As predicted, the mutant mice showed reduced behavioural and electrophysiological responses to bitter compounds, whereas they were indistinguishable from wild-type controls in their responses to salty and sour stimuli. Unexpectedly, mutant mice also exhibited reduced behavioural and electrophysiological responses to sweet compounds. Our results suggest that gustducin is a principal mediator of both bitter and sweet signal transduction.

PMID:
8657284
DOI:
10.1038/381796a0
[Indexed for MEDLINE]
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