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Mutat Res. 1996 Feb 19;350(1):69-76.

Recombination-dependent mutation in non-dividing cells.

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Department of Biochemistry, University of Alberta Faculty of Medicine, Edmonton, Canada.


Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.

[Indexed for MEDLINE]

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