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Mayo Clin Proc. 1996 Jul;71(7):636-42.

Epithelioid sarcoma: a clinicopathologic review of 55 cases.

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1
Division of Anatomic Pathology, Mayo Clinic Rochester, MN 55905, USA.

Abstract

OBJECTIVE:

To identify any clinical and pathologic features of treatment modalities that are predictive of outcome in patients with epithelioid sarcoma, a rare slow-growing soft tissue tumor most commonly occurring in the distal extremities of young adults.

DESIGN:

We reviewed the institutional files for cases of epithelioid sarcoma for the period 1956 to 1991 and analyzed the effect of various factors on survival.

MATERIAL AND METHODS:

Fifty-five cases of epithelioid sarcoma were found, and the relevant clinical, pathologic, treatment, follow-up, and outcome features were assessed.

RESULTS:

All tumors were treated initially by operative resection. The recurrence rate progressively decreased with increasing aggressiveness of the initial operation; however, no difference was noted in metastatic rate. Overall, the recurrence rate was 38% and the metastatic rate was 47%. At the end of a mean follow-up of 102 months, 69% of patients had no evidence of disease, 27% had died of the disease, and 4% were alive with disease. Increasing tumor size, necrosis of more than 30%, and vascular invasion correlated significantly with a worse prognosis.

CONCLUSION:

Epithelioid sarcoma should be considered a malignant neoplasm with a significant potential for aggressive behavior, and close follow-up of affected patients should be maintained for many years. Initial treatment should be aggressive in an attempt to prevent recurrence.

PMID:
8656704
DOI:
10.1016/S0025-6196(11)63000-0
[Indexed for MEDLINE]
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