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J Infect Dis. 1996 Jul;174(1):83-8.

Collagen binding of Staphylococcus aureus is a virulence factor in experimental endocarditis.

Author information

1
Department of Immunology, Karolinska Institute, Huddinge University Hospital, Sweden.

Abstract

The role of Staphylococcus aureus collagen binding in the development of experimental endocarditis was studied. Two isogenic strains of S. aureus, 1 carrying an insertional inactivation of the gene encoding collagen-binding protein, were compared in a rat model of catheter-induced infective endocarditis (i.e.). Separate groups of rats with traumatized aortic valves were intravenously challenged with 1 of the strains. In rats sacrificed 24 h after inoculation, the collagen-binding strain significantly outnumbered the mutant strain (P < .001); however, 1 h after challenge, there was no difference in numbers of the 2 strains. The results were substantiated, using a 1:1 mixture of the parent strain and the mutant as an inoculate. Our findings suggest that collagen binding of S. aureus is important in the sustenance of experimental IE and plays a limited role during the initial attachment of the microorganism to traumatized aortic valves.

PMID:
8656018
DOI:
10.1093/infdis/174.1.83
[Indexed for MEDLINE]

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