Format

Send to

Choose Destination
Gene. 1996 Jun 12;172(1):155-9.

Identification of a Hydra homologue of the beta-catenin/plakoglobin/armadillo gene family.

Author information

1
Laboratory of Cell and Developmental Biology, University of Frankfurt, Frankfurt/Main, Germany. Hobmayer@zoology.uni-frankfurt.d400.de

Abstract

The beta-catenin/plakoglobin/armadillo gene family encodes a group of highly conserved proteins which play important roles in cadherin-mediated cell adhesion and in signal transduction mechanisms involved in regulating development. This gene family previously had been isolated only from higher metazoans. Here, we describe the isolation and characterization of a beta-catenin (beta Ctn) homologue from Hydra magnipapillata, a diploblastic lower metazoan. Comparison of the putative amino acid (aa) sequence of Hydra beta Ctn, with its homologues in higher metazoans, shows that a repeating 42-aa motif present in its central domain is highly conserved throughout the metazoa. This suggests that beta Ctn appeared very early in metazoan evolution, possibly when primitive multicellular animals started to form epithelial cell layers.

PMID:
8654977
DOI:
10.1016/0378-1119(96)00162-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center