Send to

Choose Destination
See comment in PubMed Commons below
Cancer Res. 1996 Jun 1;56(11):2561-5.

A comparison between the efficacy of somatostatin receptor scintigraphy and that of in situ hybridization for somatostatin receptor subtype 2 messenger RNA to predict therapeutic outcome in carcinoid patients.

Author information

  • 1Department of Internal Medicine, University Hospital, Uppsala, Sweden.


Predictive tests for treatment with somatostatin analogues have been asked for by clinicians. We have shown previously that somatostatin receptor (sstr) scintigraphy may be used to predict therapeutic outcomes for carcinoid patients receiving somatostatin analogues. However, almost 20% of patients with pathological tracer uptake fail to respond to such treatment. To increase further the reliability and prognostic value of sstr identification, we investigated the presence of mRNA for the subtypes sstr1 and sstr2 by in situ hybridization on tumor specimen from 25 carcinoid patients (22 midgut, 2 foregut, and 1 hindgut), all receiving somatostatin analogue treatment (12 lanreotide, 8 octreotide, and 5 octastatin) and compared this to the therapeutic response evaluated as inhibition of hormone secretion. Expression of sstr2 mRNA could be detected in 15 patients, all responding to somatostatin analogue treatment and showing pathological tracer uptake in tumor lesions at sstr scintigraphy. In the remaining 10 patients, no sstr2 mRNA could be detected, and none of the patients responded to somatostatin analogue treatment. Three of these 10 patients failed to accumulate tracer activity at sstr scintigraphy, whereas 7 had a pathological uptake of [(111)In-DTPA-D-Phe(1)]-octreotide. We conclude that in this group of carcinoid patients, there was complete agreement between the presence of mRNA for sstr2 detected by in situ hybridization and therapeutic outcome. In patients with pathological tracer accumulation without expression of somatostatin sstr2 mRNA, other sstr may be present that can bind the somatostatin analogue but not inhibit hormone secretion.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center