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Philos Trans R Soc Lond B Biol Sci. 1996 Feb 29;351(1336):127-34.

The regulation of AP-1 activity by mitogen-activated protein kinases.

Author information

1
Department of Pharmacology, University of California, San Diego School of Medicine, La Jolla 92093, USA.

Abstract

AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed of Jun and Fos subunits. The composition, the level and the activity of AP-1 complexes are regulated in response to extracellular stimuli. An important role in this regulation is played by mitogen-activated protein kinases (MAPKs). The specific roles of three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-1, are discussed.

PMID:
8650258
DOI:
10.1098/rstb.1996.0008
[Indexed for MEDLINE]

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