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J Natl Cancer Inst. 1977 Jun;58(6):1841-4.

Origin in tobacco smoke of N'-nitrosonornicotine, a tobacco-specific carcinogen.

Abstract

To evaluate risk factors and to approach methods of reduction of the carcinogenic potential of cigarette smoke, the transfer rate of N-nitrosonornicotine in a popular U.S. blended cigarette into mainstream smoke was quantitatively determined. The mean transfer rate was 11.3%; thus approximately 46% of the tobacco-specific carcinogen in the smoke came from the tobacco, and the remainder was synthesized during smoking.

PMID:
864762
DOI:
10.1093/jnci/58.6.1841
[Indexed for MEDLINE]

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