Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Dev Biol. 1995 Oct;39(5):781-7.

Structure and function of basement membranes.

Author information

1
Department of Developmental Biology, The Wenner-Gren Institute, Stockholm University, Sweden.

Abstract

The importance of basement membranes in development and adult tissue function has been inferred from a number of observations. Cells migrate along basement membranes during development, basement membranes are required for the polarization of cells in both the embryo and the adult, and basement membranes serve as substrates for cell adhesion and migration during wound healing and nerve regeneration. The importance of basement membranes in adult tissue function has been directly demonstrated by the genetic diseases caused by mutations in the genes for structural basement membrane components. Examples of such diseases are Alport syndrome and junctional epidermolysis bullosa. Recently, defects in the major laminin variant in muscle, merosin, has been shown to be correlated with muscular dystrophies in man and animals. We are using the dystrophic mutant mouse dy, which lacks laminin-2, to analyze the function of laminin-2 in different tissues. Studies of laminin defects in animals and humans are expected to give new information on the function of basement membrane in general and on laminin in particular. Such information may give directions for future diagnosis and treatment of diseases involving basement membranes.

PMID:
8645562
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for The International Journal of Developmental Biology
    Loading ...
    Support Center