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Trends Biotechnol. 1996 May;14(5):150-2.

Controlling IGF-receptor function: a possible strategy for tumor therapy.

Author information

1
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA. baserga1@jeflin.rju.edu

Abstract

The insulin-like growth factor-1 receptor (IGF-IR) is one of several growth-factor receptors that regulate the proliferation of mammalian cells. However, its ubiquitousness and certain unique aspects of its function make IGF-IR an ideal target for therapeutic interventions against abnormal growth, with very little effect on normal cells.

PMID:
8645448
DOI:
10.1016/0167-7799(96)10023-8
[Indexed for MEDLINE]

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