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Proc Natl Acad Sci U S A. 1996 May 14;93(10):4862-7.

Crystal structure of a human TATA box-binding protein/TATA element complex.

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1
Laboratory of Molecular Biophysics, The Rockefeller University, NY 10021, USA.

Abstract

The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.

PMID:
8643494
PMCID:
PMC39370
[Indexed for MEDLINE]
Free PMC Article
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