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Cancer Lett. 1996 Jun 24;104(1):121-6.

Expression and the role of cathepsin H in human glioma progression and invasion.

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Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

Erratum in

  • Cancer Lett 1996 Oct 1;107(1):161. Chintala KS [corrected to Chintala SK].


Proteinases and their inhibitors may play a role in the development and progression of many cancers. Several studies suggested that lysosomal proteinases cathepsin B, L, and D may be involved in the malignant progression of some human neoplastic diseases. In this study, we determined the levels of cathepsin H in human glioma progression and the significance of cathepsin H in glioma cell invasion. Levels of cathepsin H antigen were found to be significantly higher in glioblastomas and anaplastic astrocytoma when compared with normal brain tissue and low-grade gliomas. Western blotting confirmed the presence of authentic cathepsin H with a doublet at 27 and 25 kDa in normal brain tissue and tumor samples. However, the intensity of the band increased significantly in glioblastoma samples. Cathepsin H antibody inhibited the invasion of glioblastoma cell lines through Matrigel invasion assay. These data suggest that the tumor-specific increase in antigen may be a useful independent marker of tumor progression in central nervous system neoplasms.

[Indexed for MEDLINE]

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