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Biochim Biophys Acta. 1996 Apr 26;1280(2):173-7.

Molecular cloning and tissue distribution of rat peptide transporter PEPT2.

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1
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Japan.

Abstract

A cDNA encoding rat H(+)- coupled peptide transporter PEPT2 was isolated. The cDNA encoded a protein of 729 amino acids with 48% amino acid identity to the rat PEPT1. The mRNA expression of rat PEPT2 was predominant in the kidney. When expressed in Xenopus oocytes, rat PEPT2 stimulated the uptake of bestatin, a dipeptide-like drug.

PMID:
8639691
DOI:
10.1016/0005-2736(96)00024-7
[Indexed for MEDLINE]
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