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Trends Neurosci. 1995 Dec;18(12):515-9.

GABAC receptors.

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1
Max-Planck-Institut für Hirnforschung, Frankfurt, Germany.

Abstract

gamma-Aminobutyric acid (GABA) is an important neurotransmitter that mediates inhibition in the vertebrate CNS. Until recently, two receptor subtypes were known: bicuculline-sensitive GABAA and baclofen-sensitive GABAB receptors. Several lines of evidence now indicate the existence of a third class of GABA receptor, which is distinct pharmacologically from GABAA and GABAB receptors and is found predominantly in the vertebrate retina. These novel GABAC receptors are Cl- pores. They are insensitive to drugs that modulate GABAA and GABAB receptors and are activated selectively by cis-4-aminoacrotonic acid.

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PMID:
8638289
[Indexed for MEDLINE]
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