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Science. 1996 Mar 1;271(5253):1289-91.

Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers.

Author information

1
Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow.

PMID:
8638112
DOI:
10.1126/science.271.5253.1289
[Indexed for MEDLINE]

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