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JAMA. 1996 Jun 5;275(21):1661-5.

The safety effects of child-resistant packaging for oral prescription drugs. Two decades of experience.

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1
Directorate for Economic Analysis, US Consumer Product Safety Commission, Washington, DC 20207, USA.

Abstract

OBJECTIVE:

To evaluate the effectiveness of child-resistant packaging in reducing the mortality rate for children younger than 5 years from the unintentional ingestion of oral prescription drugs.

DESIGN:

Annual mortality rates for children younger than 5 years associated with the unintentional ingestion of oral prescription drugs are constructed for 1964 through 1992. The effect of child-resistant packaging on the child mortality rate during the postintervention period (1974 through 1992) is evaluated with a multivariate time series regression model. The analysis controls for changes in the consumption of oral prescription drugs over time and for long-term safety trends.

SETTING:

United States.

SUBJECTS:

Children younger than 5 years.

MAIN OUTCOME MEASURE:

Estimated reductions in the child mortality rate associated with the use of child-resistant packaging.

RESULTS:

After controlling for covariates, the use of child-resistant packaging was associated with an annual reduction in the oral prescription drug-related mortality rate of 1.40 (95% confidence interval, 0.85-1.95) deaths per million children younger than 5 years. This suggests a reduction of about 460 child deaths from 1974, the year oral prescription drugs became subject to child-resistant packaging requirements, through 1992-a mortality rate reduction of about 45% from levels projected without the child-resistant requirements.

CONCLUSION:

Child-resistant packaging reduces child mortality from the unintentional ingestion of oral prescription drugs.

PMID:
8637140
[Indexed for MEDLINE]
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