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Cell Motil Cytoskeleton. 1996;33(2):88-94.

Ability of paralyzed flagella mutants of Chlamydomonas to move.

Author information

1
Department of Genetics and Cell Biology, Washington State University, Pullman 99164-4234, USA.

Abstract

Chlamydomonas mutants missing the central pair or radial spokes are paralyzed despite the fact that they have the full wild-type complement of functional dynein ATPases. We show here that these mutants can move under conditions of low ATP concentration, a combination of ATP and ADP, and a combination of ATP and ribose-modified ATP analogs. These conditions suggest an inhibitory role of ATP and that this inhibition can be relieved by ADP or analogs. The function of the central-pair/radial spoke complex may be to release this ATP inhibition in a controlled manner.

[Indexed for MEDLINE]

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