Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Vet Res. 1996 Feb;57(2):147-50.

Helicobacter mustelae-associated hypergastrinemia in ferrets (Mustela putorius furo).

Author information

  • 1Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA.

Abstract

OBJECTIVE:

To determine whether ferrets naturally infected with Helicobacter mustelae were hypergastrinemic, compared with ferrets that were specific-pathogen-free (SPF) for H mustelae.

DESIGN:

Plasma gastrin concentrations in H mustelae-infected and SPF ferrets were measured at 3 time points and compared to determine whether H mustelae was associated with hypergastrinemia.

ANIMALS:

21 H mustelae-infected ferrets and 10 SPF ferrets.

PROCEDURE:

The H mustelae status of the ferrets was confirmed prior to commencement of the study. Gastric endoscopy was used to obtain gastric mucosal pinch biopsy specimens that were processed for rapid-urease assay, microaerophilic culturing, and histologic evaluation. Plasma gastrin concentrations were determined at 3 time points: baseline after a 12-hour nonfeeding period, and 30 and 60 minutes after oral administration of a standardized meal. Gastrin was measured by radioimmunoassay.

RESULTS:

The results for the H mustelae-infected group (mean +/- SEM pg/ml) were: baseline, 54.4 +/- 2.56; 30 minutes, 94.5 +/- 6.05; and 60 minutes, 82.6 +/- 5.73. The SPF group results were: baseline, 55.8 +/- 7.35; 30 minutes, 80.8 +/- 5.77; and 60 minutes, 59.7 +/- 4.95. There was a significant (P < 0.01) difference at the 60-minute time point between the 2 groups of animals. The H mustelae group had a 17% higher mean gastrin value at 30 minutes.

CONCLUSIONS:

Helicobacter mustelae is associated with hypergastrinemia in ferrets.

CLINICAL RELEVANCE:

Helicobacter-induced hypergastrinemia may be related to the pathogenesis of peptic ulcer disease in ferrets.

PMID:
8633798
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center