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Am J Psychiatry. 1996 Jun;153(6):817-9.

Differential effect of clozapine on weight: a controlled study.

Author information

1
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA.

Abstract

OBJECTIVE:

This study examined whether clozapine induces more weight gain than haloperidol and whether weight gain is related to clinical improvement.

METHOD:

The weight and symptoms of 39 outpatients with schizophrenia who were randomly assigned to double-blind treatment with either clozapine or haloperidol were assessed. The weight and symptoms of 33 of the patients who chose to take clozapine during a 1-year follow-up after the study ended were also assessed.

RESULTS:

The patients treated with clozapine gained significantly more weight over baseline (7%) than the haloperidol-treated patients (1%). Weight gain was not significantly correlated with improvements in either positive or negative symptoms. Fifty-eight percent of the patients followed for 1 year gained at least 10% over their baseline weight.

CONCLUSIONS:

Weight gain is an important side effect of clozapine and is unrelated to the drug's differential antipsychotic efficacy.

PMID:
8633697
DOI:
10.1176/ajp.153.6.817
[Indexed for MEDLINE]

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