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Nature. 1996 May 30;381(6581):387-93.

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing.

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European Molecular Biology Laboratory, Heidelberg, Germany.

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  • Nature 1996 Jul 4;382(6586):93.


Secreted signalling molecules provide cells with positional information that organizes long-range pattern during the development of multicellular animals. Evidence is presented that localized expression of Decapentaplegic instructs cells about their position along the anterior-posterior axis of the Drosophila wing in two distinct ways. One mechanism is based on the local concentration of the secreted protein; the other is based on the ability of the cells to retain an instruction received at an earlier time when their progenitors were in close proximity to the signal. Both mechanisms are involved in axis formation.

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[Indexed for MEDLINE]

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