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J Med Chem. 1996 Feb 16;39(4):949-56.

Guanine, pyrazolo[3,4-d]pyrimidine, and triazolo[4,5-d]pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase.

Author information

1
Burroughs Wellcome Co., Research Triangle Park, North Carolina 27709, USA.

Abstract

Phosphonate acyclic derivates of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with Ki' values ranging from 0.05 to 1.6 microM. These compounds are enzymatically stable congeners of the potent PNPase inhibitor acyclovir diphosphate (53).

PMID:
8632418
DOI:
10.1021/jm950736k
[Indexed for MEDLINE]

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