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Arthritis Rheum. 1996 Apr;39(4):657-62.

Hair dye use and the risk of developing systemic lupus erythematosus.

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1
Harvard Medical School, Boston, Massachusetts, USA.

Abstract

OBJECTIVE:

To investigate the role of hair dye use in the etiology of systemic lupus erythematosus (SLE).

METHODS:

Participants included 106,391 women enrolled in the Nurses' Health Study, a prospective cohort study. The subjects were ages 30-55 years in 1976, and were free from SLE and any other connective tissue disease at the time of enrollment. In 1976, 1978, 1980, and 1982, subjects were classified as never-users or ever-users of permanent hair dye, based on self-report. Incidence rates of SLE meeting American College of Rheumatology classification criteria were ascertained and confirmed by chart review.

RESULTS:

Compared with never-users of permanent hair dye, the age-adjusted relative risks (RR) for the development of SLE among ever-users (n = 85 cases) was 0.96 (95% confidence interval [95% CI] 0.63-1.47). Duration of hair dye use was not related to risk of SLE. Women with 15 or more years of use had no increased risk (RR = 0.92, 95% CI 0.46-1.83). There was no relationship between frequency of use or time since first use and risk of SLE. The results were similar when less stringent criteria for SLE were used.

CONCLUSION:

We found no evidence that permanent hair dye use, age at first use, frequency of use, or duration of use is associated with the development of SLE.

PMID:
8630117
[Indexed for MEDLINE]

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