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Biochem Biophys Res Commun. 1996 May 6;222(1):101-6.

Effect of hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes in rats.

Author information

1
Second Department of Surgery, Asahikawa Medical College, Japan.

Abstract

The effect of human hepatocyte growth factor on the proliferation of intrasplenically transplanted hepatocytes was investigated. A human hepatocyte growth factor (360 micrograms/kg BW) was administered intravenously every 24 hr for 5 days following hepatocyte transplantation in rats. A significant increase in hepatocyte proliferation was observed morphologically and immunohistochemically (p < 0.05). The bromodexyuridine labeling index was significantly greater in human hepatocyte growth factor treated rats than in the control rats (p < 0.05). Hepatocyte growth factor may promote the proliferation of intrasplenically transplanted hepatocytes.

PMID:
8630051
DOI:
10.1006/bbrc.1996.0704
[Indexed for MEDLINE]

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