Evidence for involvement of equine herpesvirus 1 glycoprotein B in cell-cell fusion

Arch Virol. 1996;141(1):167-75. doi: 10.1007/BF01718598.

Abstract

Monoclonal antibodies specific for equine herpesvirus 1 (EHV-1) glycoproteins (gB, gD, gp2 and a cleaved translation product of gene 71) were tested for ability to inhibit cell-cell fusion as measured by syncytium formation in EHV-1 infected cell cultures. Syncytium formation was inhibited by a complement-dependent neutralising antibody (7B10) which recognised the large subunit of EHV-1 gB. This indicated that EHV-1 gB, in common with gB homologues of herpes simplex virus and other herpesviruses, plays a role in the cell-cell fusion process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / pharmacology*
  • Cell Fusion* / drug effects
  • Cell Line
  • Genes, Viral
  • Giant Cells
  • Herpesvirus 1, Equid / physiology*
  • Horses
  • Mice
  • Mice, Inbred BALB C / immunology
  • Viral Envelope Proteins / biosynthesis
  • Viral Envelope Proteins / immunology
  • Viral Envelope Proteins / physiology*

Substances

  • Antibodies, Monoclonal
  • Viral Envelope Proteins