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J Med Chem. 1996 Apr 26;39(9):1864-71.

Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci.

Author information

1
F. Hoffmann-La Roche Ltd., Basel, Switzerland.

Abstract

The synthesis and structure-activity relationships of a new class of vinylcephalosporins substituted with a lactamyl residue are described. These compounds show excellent activity against enterococci and retain the broad spectrum activity of third-generation cephalosporins such as ceftriaxone.

PMID:
8627610
DOI:
10.1021/jm950886v
[Indexed for MEDLINE]

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