Format

Send to

Choose Destination
J Pediatr. 1996 May;128(5 Pt 1):695-7.

Conjugated bilirubin in neonates with glucose-6-phosphate dehydrogenase deficiency.

Author information

1
Department of Neonatology, Shaare Zedek Medical Center, Medical School, Hebrew University-Hadassah, Jerusalem, Israel.

Abstract

We used a system capable of measuring conjugated bilirubin and its monoconjugated and diconjugated fractions in serum to assess bilirubin conjugation in 29 glucose-6-phosphate dehydrogenase (G6PD)-deficient, term, male newborn infants and 35 control subjects; all had serum bilirubin levels > or = 256 mumol/L (15 mg/dI). The median value for diconjugated bilirubin was lower in the G6PD-deficient neonates than in control subjects (0.06 (range 0.00 to 1.84) vs 0.21 (range 0.00 to 1.02) mumol/L, p = 0.006). Diglucuronide was undetectable in 11 (38.9%) of the G6PD-deficient infants versus 3 (8.6%) of the control subjects (p = 0.015). These findings imply a partial defect of bilirubin conjugation not previously demonstrated in G6PD-deficient newborn infants.

PMID:
8627445
DOI:
10.1016/s0022-3476(96)80138-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center