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J Bacteriol. 1996 May;178(9):2712-4.

Intracellular inducer Hg2+ concentration is rate determining for the expression of the mercury-resistance operon in cells.

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1
Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, 60612-7344, USA.

Abstract

Experiments involving mercury resistance mer operon-lacZ fusions, point mutations in the mercuric ion reductase merA gene, and transcomplementation have revealed that in Hg2+-resistant cells, the inducer Hg2+ concentration is rate determining for activation of transcription. mer operon expression is activated by the presence of nanomolar concentrations of Hg2+ in liquid media only when the mercuric ion reductase function is artificially inactivated in cells, whereas cells with active mercuric ion reductase require micromolar concentrations of Hg2+ for effective induction of the operon.

PMID:
8626343
PMCID:
PMC178000
[Indexed for MEDLINE]
Free PMC Article
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