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Clin Exp Immunol. 1996 May;104(2):318-24.

Elevation of plasma-soluble tumour necrosis factor receptors (TNF-R) in sarcoidosis.

Author information

1
First Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.

Abstract

Two types of receptor for tumour necrosis factor-alpha (TNF-R), the 55-kD receptor (TNF-RI) and the 75-kD receptor (TNF-RII), have been identified. Soluble TNF-RI (sTNF-RI) and soluble TNF-RII (sTNF-RII) can be measured in culture supernatants and biological fluids, and the role of sTNF-R has been suggested. In the present study, we measured plasma sTNF-RI and sTNF-RII levels in 19 patients with active sarcoidosis by ELISA in order to assess the state of both types of receptors in this disease. Both plasma sTNF-RI and sTNF-RII levels in patients with active sarcoidosis were significantly higher than those in normal control subjects. A longitudinal evaluation of plasma sTNF-RI and sTNF-RII levels showed that the magnitude of changes in sTNF-RII was closely related with the clinical course of sarcoidosis. These results suggest that plasma sTNF-RII levels may be useful parameters for monitoring the clinical course of sarcoidosis as well as markers for identifying disease activity.

PMID:
8625527
PMCID:
PMC2200429
DOI:
10.1046/j.1365-2249.1996.13702.x
[Indexed for MEDLINE]
Free PMC Article

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