Format

Send to

Choose Destination
Br J Obstet Gynaecol. 1996 May;103(5):442-5.

Serum levels of endometrial proteins during transcervical resection of the endometrium.

Author information

1
Department of Anaesthesia, Stockholm South Hospital, Sweden.

Abstract

OBJECTIVE:

To study the potential for dissemination of endometrial tissue substances during transcervical resection of the endometrium (TCRE).

DESIGN:

Prospective study.

SETTING:

One university and two county hospitals.

PARTICIPANTS:

Forty-eight women with dysfunctional bleeding.

INTERVENTIONS:

The serum levels of two endometrial proteins, insulin-like growth factor binding protein-1 (IGFBP-1) and placental protein 14 (PP14), were measured before and every 10 min during the operations. Blood loss was also measured by a photometer together with absorption of the irrigating fluid containing glycine 1.5% and ethanol 1% by expired-breath tests, and serum sodium and volumetric fluid balances.

MAIN OUTCOME MEASURES:

Linear correlations between changes in IGFBP-1 and PP14 during TCRE and operating parameters such as operating time, blood loss and fluid absorption.

RESULTS:

The baseline levels of IGFBP-1 were normal but PP14 could only be detected in one third of the patients, which was due, in part, to pre-operative treatment with danazol. The highest levels of IGFBP-1 and PP14 during surgery correlated positively with the baseline concentrations. Fluid absorption (median 405 ml, range 0-2177) was the only surgical factor associated with increasing serum levels of endometrial proteins.

CONCLUSION:

Absorption of the solution used to irrigate the uterus is associated with dissemination of endometrial products in the bloodstream during TCRE.

PMID:
8624317
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center