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Magn Reson Med. 1996 Feb;35(2):143-8.

Dynamic uncoupling and recoupling of perfusion and oxidative metabolism during focal brain activation in man.

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Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie Am Fassberg 11, Göttingen, Germany.


Changes in glucose consumption, lactate production, and blood oxygenation were measured during prolonged neuronal activation (4-6 min) in human primary visual cortex using dynamic magnetic resonance spectroscopy and imaging. A decrease of steady-state glucose by 40% because of enhanced use by 21% was accompanied by a transient accumulation of lactate with a peak value of 170% 2.5 min after stimulation onset. Rapid blood hyperoxygenation indicating "uncoupling" of blood flow and oxidative metabolism was followed by a return to basal levels over 3 min. Thus, initial nonoxidative glucose consumption during functional activation is gradually complemented by a slower adjustment of oxidative phosphorylation that "recouples" perfusion and oxygen consumption at a new equilibrium.

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