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Life Sci. 1996;58(17):1461-7.

The endogenous estrogen metabolite 2-methoxyestradiol induces apoptotic neuronal cell death in vitro.

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1
Laboratory of Neurochemistry, Snow Brand Milk Products, Tochigi, Japan.

Abstract

We examined the effects of 2-methoxyestradiol, a metabolite of estradiol, on cell death in retinoic acid (RA)-differentiated neuroblastoma SH-SY5Y cell cultures. Cell death was induced by 2-methoxyestradiol in a concentration-dependent manner. Estradiol and 2-methoxyestradiol failed to induce cell death. The cell death response to 2-methoxyestradiol was sensitive to the protein synthesis inhibitor cycloheximide and the apopain inhibitor Ac-Asp-Glu-Val-Asp-H(aldehyde). 2-Methoxyestradiol also induced internucleosomal for and endogenous neuroactive steroid metabolite in the etiology of some neurodegenerative diseases.

PMID:
8622572
DOI:
10.1016/0024-3205(96)00116-6
[Indexed for MEDLINE]

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