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J Clin Invest. 1996 Apr 15;97(8):1837-43.

Nitric oxide inhibits viral replication in murine myocarditis.

Author information

1
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Abstract

Nitric oxide (NO) is a radical molecule that not only serves as a vasodilator and neurotransmitter but also acts as a cytotoxic effector molecule of the immune system. The inducible enzyme making NO, inducible NO synthase (iNOS), is transcriptionally activated by IFN-gamma and TNF-alpha, cytokines which are produced during viral infection. We show that iNOS is induced in mice infected with the Coxsackie B3 virus. Macrophages expressing iNOS are identified in the hearts and spleens of infected animals with an antibody raised against iNOS. Infected mice have increased titers of virus and a higher mortality when fed NOS inhibitors. Thus, viral infection induces iNOS in vivo, and NO inhibits viral replication. NO is a novel, nonspecific immune defense against viruses in vivo.

PMID:
8621766
PMCID:
PMC507251
DOI:
10.1172/JCI118613
[Indexed for MEDLINE]
Free PMC Article

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